Michael K. Pugsley's Cardiac Drug Development Guide (Methods in Pharmacology and PDF

By Michael K. Pugsley

ISBN-10: 1588290972

ISBN-13: 9781588290977

ISBN-10: 1592594042

ISBN-13: 9781592594047

Cardiac Drug improvement consultant outlines, intimately, the therapeutics of cardiac medication at present on the leading edge of medical examine and improvement all over the world. This quantity integrates simple and medical cardiac pharmacology via c- bining, for the 1st time, either classical and molecular elements of healing drug improvement. The chapters include a huge spectrum of healing components and as a result contain a entire dialogue of molecular, biochemical, and electrophy- ological techniques in accordance with years of in vitro in addition to in vivo pharmacological st- ies. moreover, the latter a part of the e-book comprises accomplished scientific cardiac chapters that describe vital issues in molecular drugs. those chapters additionally talk about present medical healing traits in drugs and supply an overview of the efficacy of novel medicines in those components. Cardiac Drug improvement advisor has many certain and notable good points that set it except different cardiac pharmacology books. This booklet introduces issues in an simply comprehensible structure for researchers in lots of various disciplines through integrating and thereby simplifying recommendations now not often mentioned throughout a wide variety of cardiac disciplines and in a hugely technical box. every one bankruptcy not just introduces and describes the body structure, pharmacology, and pathophysiology of the disorder, but in addition overviews the medical implications of drug improvement, what phases those components are at present in, and likewise stories a number of the methodologies all for drug discovery and improvement. for this reason, this booklet offers a complete assessment of the main complex tactics in cardiac pharmacology this day.

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Extra resources for Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology)

Sample text

1994) Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node. J. Physiol. 474, 473–482. 28. Accili, E. , and DiFrancesco, D. (1997) Differential control of the hyperpolarization-activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino-atrial node myocytes. J. Physiol. 500, 643–651. 29. , Cohen, I. , Rosen, M. , and Tromba, C. (1991) Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f).

However, when it was first described, there was initially some skepticism regarding the role of I(f) in pacemaking and, indeed, there is still some degree of controversy as to just how important I(f) is to pacemaking (19,20). Although I(f) seems to be a good candidate for the role of a pacemaker current, the real situation is somewhat more complex. An important caveat is that, rather than being driven by one current, the pacemaking activity of SAN cells is a product of the interplay of many currents (21).

Morales, M. , Campbell, D. , Brahmajothi, M. , and Strauss, H. C. (1998) Inactivation of voltage-gated cardiac K+ channels. Circ. Res. 82, 739–750. 33. Colatsky, T. J. and Follmer, C. H. (1989) K+ channel blockers and activatorrs in cardiac arrhythmias. Cardiovasc. Drug Rev. 7, 199–209. 34. Hondeghem, L. M. and Snyders, D. J. (1990) Class III antiarrhythmic agents have a lot of potential but a long way to go. Circulation 81, 686–690. 35. , and Camm, A. J. (1993) New class III antiarrhythmic drugs.

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Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology) by Michael K. Pugsley

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