Burger's Medicinal Chemistry and Drug Discovery, - download pdf or read online

By Donald A. Abraham

ISBN-10: 0471370290

ISBN-13: 9780471370291

His is quantity three: Cardiovascular brokers and Endocrines, of Burger's Medicinal Chemistry and Drug Discovery, sixth version. This new quantity includes serious new chapters on Endogenous Vasoactive Peptides, Iron Chelators and healing makes use of, and basics of Steroid Chemistry and Biochemistry.

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Extra info for Burger's Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines

Sample text

Such drugs include propranolol (Inderal), a and P blockers labetalol (Normdyne, Trandate), acebutolol (Sectral), atenolol (Tenormin), metopro101 (Toprol), and bisoprolol (Zebeta). These drugs are equally effective as calcium channel blockers and have fewer adverse effects. 7 Glycoprotein Ilb/llla Receptor Antagonists. These compounds are also called blood thinners because they block platelet activity. These drugs are very beneficial for many patients with angina and do not seem to pose an increased risk for stroke, including strokes caused by bleeding.

It is usually administered either orally or by slow continuous IV infusion (when oral administration is not viable), for the treatment of chronic stable angina and the short-term management of hypertension. It is used as a monotherapy or in combination with other antianginal or antihypertensive drugs. Nifedipine (30) (Fig. 3): The principle physiological action of nifedipine is similar to other 1,4-dihydropyridine derivatives. This drug functions by inhibiting the transmembrane influx of extracellular calcium ions across the myocardial membrane and vascular smooth muscle cells, without affecting plasma calcium concentrations.

Sodium channel blockade, lengthen refractory period Sodium channel blockade, shorten duration of action potential Sodium channel blockade, conduction slowed Blockade of p-adrenergic receptors, AV conduction time slowed, automaticity suppressed Potassium channel blockade, prolonged refractoriness Blockade of slow inward Ca2+ Miscellaneous 4. The metabolites of many of the antiarrhythmic drugs also contribute to their potency (for example, lorcainide and its metabolite, norlorcainide, are both active antiarrhythmic agents).

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Burger's Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines by Donald A. Abraham

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